At the Institute of Information Systems (IIS) of the Leuphana University we work on innovative topics in Information Systems and Data Science. The main focus is on digital transformation, e-health, e-commerce, business analytics, sports and e-learning. Methodologically, we focus on the development and use of machine learning and artificial intelligence methods for the modeling and solution of data-driven decision problems. Additional quantitative (e.g. graphs, optimization) and qualitative (e.g. interviews, reference modeling) methods complement this spectrum. Cooperating with other universities, companies, and institutions of the civil society plays an important role in our work.